Synthesis and Characterization of Transferrin Receptor-Targeted Peptide Combination SN-38 and Rucaparib Conjugate for the Treatment of Glioblastoma

Synthesis and Characterization of Transferrin Receptor-Targeted Peptide Combination SN-38 and Rucaparib Conjugate for the Treatment of Glioblastoma

<b>Background/Objectives:</b> Glioblastoma represents a particularly aggressive and fatal type of brain tumor. Peptide-drug conjugates, which offer the promise of traversing the blood-brain barrier to selectively accumulate in tumor tissues and precisely target cancer cells, are an activ...

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Bibliographic Details
Main Authors: Perpetue Bataille Backer, Simeon Kolawole Adesina
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
glioblastoma
peptide drug conjugate
SN-38
rucaparib
cathepsin B
combination therapy
Online Access:https://www.mdpi.com/1999-4923/17/6/732
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