Rational adjuvant selection for the neonatal period shapes unique and lasting immune polarization in mice

Abstract A major knowledge gap exists in understanding immune effects of adjuvants in early life. As environmental stimuli shape the infant immune system, adjuvants may also influence this process. Using a neonatal mouse model, we investigated the differential effects of adjuvants in neonates vs. ad...

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Bibliographic Details
Main Authors: Chun Chen, Olivia E. Benson, Taylor Simmons, Chris L. Dorsett, Katarzyna W. Janczak, Matthew J. Wiest, Mohammad Farazuddin, James R. Baker, Pamela T. Wong, Jessica J. O’Konek
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01227-5
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