Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy

Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy

Abstract The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is a critical signaling network governing cellular functions such as immune responses, proliferation, and apoptosis. Dysregulation of this pathway is strongly implicated in cancer progression. This review e...

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Bibliographic Details
Main Authors: Bhagyalakshmi Nair, Anjana Menon, M. Rithwik Kalidas, Lekshmi R. Nath, Daniela Calina, Javad Sharifi-Rad
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
JAK/STAT pathway
Natural products
Cancer therapy
Phytochemicals
Anticancer mechanisms
Molecular targeted therapy
Online Access:https://doi.org/10.1007/s12672-025-02369-7
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https://doi.org/10.1007/s12672-025-02369-7

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