Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields

Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields

<b>Background:</b> Modern viral vector production needs to consider process intensification for higher yields from smaller production volumes. However, innate antiviral immunity triggered in the producer cell may limit virus replication. While commonly used cell lines (e.g., Vero or E1A-...

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Bibliographic Details
Main Authors: Sven Göbel, Tilia Zinnecker, Ingo Jordan, Volker Sandig, Andrea Vervoort, Jondavid de Jong, Jean-Simon Diallo, Peter Satzer, Manfred Satzer, Kai Dallmeier, Udo Reichl, Yvonne Genzel
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
bioprocess engineering
vectored live-attenuated vaccines
viral sensitizers
small molecules
design of experiments
antiviral defense
Online Access:https://www.mdpi.com/2076-393X/13/7/757
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