Homocysteine induces ferroptosis in renal tubular epithelial cells via β-catenin/GPX4 signaling pathway

Homocysteine induces ferroptosis in renal tubular epithelial cells via β-catenin/GPX4 signaling pathway

Abstract Hyperhomocysteinemia can cause severe damage to kidney. Ferroptosis represents a critical mechanism in the initiation and development of kidney disorders. We focus on the β-catenin/GPX4 signaling pathway to explore how homocysteine influences ferroptosis regulation in renal tubular epitheli...

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Bibliographic Details
Main Authors: Yanping Lei, Hengjing Hu, Huifang Tang, Lewu Xu, Rui Liu, Yue Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hyperhomocysteinemia
Ferroptosis
Β-catenin
GPX4
Renal tubular epithelial cells
Online Access:https://doi.org/10.1038/s41598-025-09221-6
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https://doi.org/10.1038/s41598-025-09221-6

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