The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint

Abstract Background & Aims ICC is a malignant tumor that originates from the intrahepatic bile ducts with insidious symptoms and a poor prognosis. Early diagnosis methods and therapeutic targets are urgently needed for ICC. Methods We utilized a comprehensive set of analytical techniques to eluc...

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Bibliographic Details
Main Authors: Wenze Wan, Yuan Li, Wentao Sun, Zewei Cheng, Fen Ma, Sheng Shen, Houbao Liu, Jiwei Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Intrahepatic Cholangiocarcinoma
Tumor-associated antigen
Progression
Immune evasion
Doublecortin domain containing 2
Enolase 1
Online Access:https://doi.org/10.1186/s13046-025-03436-1
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https://doi.org/10.1186/s13046-025-03436-1

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