Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors?
Childhood cancer survivors are in augmented risk for developing obesity. For many factors leptin and leptin receptor gene polymorphism play an important role in the development and metabolism not only of fat, but also, bone tissue. The aim of the analysis was to find the relationships between Q2...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/805312 |
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| author | Malgorzata Sawicka-Żukowska Maryna Krawczuk-Rybak Katarzyna Muszynska-Roslan Anna Panasiuk Eryk Latoch Jerzy Konstantynowicz |
| author_facet | Malgorzata Sawicka-Żukowska Maryna Krawczuk-Rybak Katarzyna Muszynska-Roslan Anna Panasiuk Eryk Latoch Jerzy Konstantynowicz |
| author_sort | Malgorzata Sawicka-Żukowska |
| collection | DOAJ |
| description | Childhood cancer survivors are in augmented risk for developing obesity. For many factors leptin and leptin receptor gene polymorphism play an important role in the development and metabolism not only of fat, but also, bone tissue. The aim of the analysis was to find the relationships between Q223R, leptin levels, and anthropometric parameters. Patients and Methods. In the study 74 cancer survivors participated (ALL n=64, lymphomas n=10), and the control group consisted of 51 healthy peers. Leptin blood concentration was determined by ELISA method. To estimate leptin receptor gene polymorphism, RFLP method was used. Bone mineral density (BMD) and content (BMC), fat, and lean tissue measurements were obtained by DXA. Results. We found no correlations between serum leptin concentrations and anthropometric parameters nor BMD. Serum leptin concentrations were significantly lower in the group of cancer survivors compared to controls; however, in those overweight from examined group we found leptin levels higher than those in nonoverweight. Genotype Q223R was not associated with higher leptin levels, BMI, BMD, body fat or lean tissue. Conclusion. To our knowledge, this is the first report describing the relationship between BMD and Q223R polymorphism in childhood cancer survivors. Further analysis, based on a larger group of patients, is needed to confirm these findings. |
| format | Article |
| id | doaj-art-654fde811c854c5985d04025300f9e23 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-654fde811c854c5985d04025300f9e232025-02-03T00:59:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/805312805312Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors?Malgorzata Sawicka-Żukowska0Maryna Krawczuk-Rybak1Katarzyna Muszynska-Roslan2Anna Panasiuk3Eryk Latoch4Jerzy Konstantynowicz5Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, PolandChildhood cancer survivors are in augmented risk for developing obesity. For many factors leptin and leptin receptor gene polymorphism play an important role in the development and metabolism not only of fat, but also, bone tissue. The aim of the analysis was to find the relationships between Q223R, leptin levels, and anthropometric parameters. Patients and Methods. In the study 74 cancer survivors participated (ALL n=64, lymphomas n=10), and the control group consisted of 51 healthy peers. Leptin blood concentration was determined by ELISA method. To estimate leptin receptor gene polymorphism, RFLP method was used. Bone mineral density (BMD) and content (BMC), fat, and lean tissue measurements were obtained by DXA. Results. We found no correlations between serum leptin concentrations and anthropometric parameters nor BMD. Serum leptin concentrations were significantly lower in the group of cancer survivors compared to controls; however, in those overweight from examined group we found leptin levels higher than those in nonoverweight. Genotype Q223R was not associated with higher leptin levels, BMI, BMD, body fat or lean tissue. Conclusion. To our knowledge, this is the first report describing the relationship between BMD and Q223R polymorphism in childhood cancer survivors. Further analysis, based on a larger group of patients, is needed to confirm these findings.http://dx.doi.org/10.1155/2013/805312 |
| spellingShingle | Malgorzata Sawicka-Żukowska Maryna Krawczuk-Rybak Katarzyna Muszynska-Roslan Anna Panasiuk Eryk Latoch Jerzy Konstantynowicz Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? International Journal of Endocrinology |
| title | Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? |
| title_full | Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? |
| title_fullStr | Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? |
| title_full_unstemmed | Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? |
| title_short | Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? |
| title_sort | does q223r polymorphism of leptin receptor influence on anthropometric parameters and bone density in childhood cancer survivors |
| url | http://dx.doi.org/10.1155/2013/805312 |
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