Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells

Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells

Abstract Background The combination of epirubicin, cisplatin, and 5-fluorouracil (ECF) is widely used for gastric cancer treatment. However, cancer cells can acquire chemoresistance over multiple treatment cycles, leading to recurrence. This study aimed to investigate a novel biomarker for predictin...

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Bibliographic Details
Main Authors: Hyo Shik Shin, Jae-Il Choi, Hye Won Chung, Hee Jung Park, Hak Park, John Hoon Rim, Jong-Baeck Lim
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Biomarker Research
Subjects:
Ninjurin2
Chemoresistance
Gastric cancer cells
Cancer initiating cells
Organoid
Online Access:https://doi.org/10.1186/s40364-025-00792-0
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https://doi.org/10.1186/s40364-025-00792-0

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