Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis
We report the case of a 58-year-old immunocompetent man presenting with fever, cough, anorexia, weight loss, and cervical lymphadenopathy. Blood investigations revealed severe neutropenia with monocytosis. Chest imaging showed bilateral reticular infiltrates with mediastinal widening. Bronchoalveola...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/865909 |
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| _version_ | 1832564611043295232 |
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| author | Merlin Thomas Mushtak AlGherbawe |
| author_facet | Merlin Thomas Mushtak AlGherbawe |
| author_sort | Merlin Thomas |
| collection | DOAJ |
| description | We report the case of a 58-year-old immunocompetent man presenting with fever, cough, anorexia, weight loss, and cervical lymphadenopathy. Blood investigations revealed severe neutropenia with monocytosis. Chest imaging showed bilateral reticular infiltrates with mediastinal widening. Bronchoalveolar lavage culture and molecular test were positive for Mycobacterium tuberculosis and treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol was started. Although pulmonary tuberculosis could explain this clinical presentation we suspected associated blood dyscrasias in view of significant monocytosis and mild splenomegaly. Bone marrow aspiration revealed acute myeloid leukemia. Thereafter the patient received induction chemotherapy and continued antituberculous treatment. After first induction of chemotherapy patient was in remission and successfully completed 6 months antituberculosis therapy without any complications. To our knowledge there has been no such case reported from the State of Qatar to date. |
| format | Article |
| id | doaj-art-6542d1d62f92432f9b8e1a43ec379ca5 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-6542d1d62f92432f9b8e1a43ec379ca52025-02-03T01:10:39ZengWileyCase Reports in Infectious Diseases2090-66252090-66332014-01-01201410.1155/2014/865909865909Acute Myeloid Leukemia Presenting with Pulmonary TuberculosisMerlin Thomas0Mushtak AlGherbawe1Pulmonary Medicine, Hamad General Hospital, P.O. Box 3050, Doha, QatarDepartment of Medicine, Hamad General Hospital, Doha, QatarWe report the case of a 58-year-old immunocompetent man presenting with fever, cough, anorexia, weight loss, and cervical lymphadenopathy. Blood investigations revealed severe neutropenia with monocytosis. Chest imaging showed bilateral reticular infiltrates with mediastinal widening. Bronchoalveolar lavage culture and molecular test were positive for Mycobacterium tuberculosis and treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol was started. Although pulmonary tuberculosis could explain this clinical presentation we suspected associated blood dyscrasias in view of significant monocytosis and mild splenomegaly. Bone marrow aspiration revealed acute myeloid leukemia. Thereafter the patient received induction chemotherapy and continued antituberculous treatment. After first induction of chemotherapy patient was in remission and successfully completed 6 months antituberculosis therapy without any complications. To our knowledge there has been no such case reported from the State of Qatar to date.http://dx.doi.org/10.1155/2014/865909 |
| spellingShingle | Merlin Thomas Mushtak AlGherbawe Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis Case Reports in Infectious Diseases |
| title | Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis |
| title_full | Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis |
| title_fullStr | Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis |
| title_full_unstemmed | Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis |
| title_short | Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis |
| title_sort | acute myeloid leukemia presenting with pulmonary tuberculosis |
| url | http://dx.doi.org/10.1155/2014/865909 |
| work_keys_str_mv | AT merlinthomas acutemyeloidleukemiapresentingwithpulmonarytuberculosis AT mushtakalgherbawe acutemyeloidleukemiapresentingwithpulmonarytuberculosis |