Gene sco1417 encodes a positive regulator of the de novo biosynthesis of pyridoxal 5ʹ-phosphate (vitamin B6) in Streptomyces coelicolor M145

Gene sco1417 encodes a positive regulator of the de novo biosynthesis of pyridoxal 5ʹ-phosphate (vitamin B6) in Streptomyces coelicolor M145

Abstract Background Actinomycetes of the genus Streptomyces are renowned for their highly developed and diverse specialized metaboliс pathways, and there is an extensive body of data on their specific and pleiotropic levels of regulation. Much less is known about routes leading to essential metaboli...

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Main Authors: Olga Tsypik, Roman Makitrynskyy, Elisabeth Gauger, Agnieszka Mitulski, Andreas Bechthold, Klas Flärdh, Wolfgang Wohlleben, Bohdan Ostash
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
Vitamin B6
PLP
Genes
Mutation
Streptomyces coelicolor A3(2)
GntR type regulators
Online Access:https://doi.org/10.1186/s12866-025-04108-y
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https://doi.org/10.1186/s12866-025-04108-y

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