Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.

The testis is a reservoir for viruses that can cause persistent infection and adversely affect male reproductive health, an observation commonly attributed to deficiencies in inducible antiviral defence mechanisms. In this study, we demonstrate that interferon-epsilon (IFNε), a type I interferon ini...

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Main Authors: Rukmali Wijayarathna, Eveline D de Geus, Rosemary Genovese, Linden J Gearing, Georgie Wray-McCann, Rajini Sreenivasan, Hiba Hasan, Monika Fijak, Peter Stanton, Daniela Fietz, Adrian Pilatz, Hans-Christian Schuppe, Michelle D Tate, Paul J Hertzog, Mark P Hedger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012702
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author Rukmali Wijayarathna
Eveline D de Geus
Rosemary Genovese
Linden J Gearing
Georgie Wray-McCann
Rajini Sreenivasan
Hiba Hasan
Monika Fijak
Peter Stanton
Daniela Fietz
Adrian Pilatz
Hans-Christian Schuppe
Michelle D Tate
Paul J Hertzog
Mark P Hedger
author_facet Rukmali Wijayarathna
Eveline D de Geus
Rosemary Genovese
Linden J Gearing
Georgie Wray-McCann
Rajini Sreenivasan
Hiba Hasan
Monika Fijak
Peter Stanton
Daniela Fietz
Adrian Pilatz
Hans-Christian Schuppe
Michelle D Tate
Paul J Hertzog
Mark P Hedger
author_sort Rukmali Wijayarathna
collection DOAJ
description The testis is a reservoir for viruses that can cause persistent infection and adversely affect male reproductive health, an observation commonly attributed to deficiencies in inducible antiviral defence mechanisms. In this study, we demonstrate that interferon-epsilon (IFNε), a type I interferon initially discovered in female reproductive epithelia, is constitutively expressed by meiotic and post-meiotic spermatogenic cells, Leydig cells and macrophages in mouse testes. A similar distribution pattern was observed in human testes. Mice lacking IFNɛ were more susceptible to Zika virus-induced inflammation and damage of the testis and epididymis compared to wild-type mice. Exogenous IFNε treatment reduced the viral infection burden in cultured human testicular cells by inducing interferon-stimulated gene expression, and reducing inflammatory gene expression and cell damage. Treatment was more effective when administered prior to infection. These data indicate a critical role for constitutively-expressed IFNɛ in limiting viral infection and inflammatory damage in the male reproductive tract.
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issn 1553-7366
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publishDate 2024-12-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS Pathogens
spelling doaj-art-653aa5223e4941eeb2eb9914ea8090552025-08-20T02:36:58ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-12-012012e101270210.1371/journal.ppat.1012702Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.Rukmali WijayarathnaEveline D de GeusRosemary GenoveseLinden J GearingGeorgie Wray-McCannRajini SreenivasanHiba HasanMonika FijakPeter StantonDaniela FietzAdrian PilatzHans-Christian SchuppeMichelle D TatePaul J HertzogMark P HedgerThe testis is a reservoir for viruses that can cause persistent infection and adversely affect male reproductive health, an observation commonly attributed to deficiencies in inducible antiviral defence mechanisms. In this study, we demonstrate that interferon-epsilon (IFNε), a type I interferon initially discovered in female reproductive epithelia, is constitutively expressed by meiotic and post-meiotic spermatogenic cells, Leydig cells and macrophages in mouse testes. A similar distribution pattern was observed in human testes. Mice lacking IFNɛ were more susceptible to Zika virus-induced inflammation and damage of the testis and epididymis compared to wild-type mice. Exogenous IFNε treatment reduced the viral infection burden in cultured human testicular cells by inducing interferon-stimulated gene expression, and reducing inflammatory gene expression and cell damage. Treatment was more effective when administered prior to infection. These data indicate a critical role for constitutively-expressed IFNɛ in limiting viral infection and inflammatory damage in the male reproductive tract.https://doi.org/10.1371/journal.ppat.1012702
spellingShingle Rukmali Wijayarathna
Eveline D de Geus
Rosemary Genovese
Linden J Gearing
Georgie Wray-McCann
Rajini Sreenivasan
Hiba Hasan
Monika Fijak
Peter Stanton
Daniela Fietz
Adrian Pilatz
Hans-Christian Schuppe
Michelle D Tate
Paul J Hertzog
Mark P Hedger
Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
PLoS Pathogens
title Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
title_full Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
title_fullStr Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
title_full_unstemmed Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
title_short Interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection, inflammation and damage.
title_sort interferon epsilon is produced in the testis and protects the male reproductive tract against virus infection inflammation and damage
url https://doi.org/10.1371/journal.ppat.1012702
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