Choline metabolism modulates cyclic-di-GMP signaling and virulence of Pseudomonas aeruginosa in a macrophage infection model

Choline metabolism modulates cyclic-di-GMP signaling and virulence of Pseudomonas aeruginosa in a macrophage infection model

Abstract Background Bacterial pathogens frequently encounter host-derived metabolites during their colonization and invasion processes, which can serve as nutrients, antimicrobial agents, or signaling molecules for the pathogens. The essential nutrient choline (Cho) is widely known to be utilized by...

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Main Authors: Yachun Zhou, Yu Zhang, Xiangke Duan, Tian Zhou, Anmin Ren, Yinyue Deng, Lin Zhong, Lei Liu, Yingfeng Huang, Weidong Zheng, Dongjing Liu, Liang Yang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Infectious Diseases
Subjects:
Pseudomonas aeruginosa
Choline metabolism
Cyclic-di-GMP
Virulence
Biofilm
Online Access:https://doi.org/10.1186/s12879-024-10375-3
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https://doi.org/10.1186/s12879-024-10375-3

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