Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat

Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat

The treatment of orofacial pain disorders is poor. Both opioids and serotonin agonists are commonly used; however, they produce dangerous and unpleasant side effects. Therefore, there is an urgent need to identify new pharmacological treatments that can resolve orofacial pain. Moreover, a treatment...

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Main Authors: Daniel Carr, Siena Gunari, Gabrielle Gorostiza, Madison Mercado, Lucy Pavana, Leah Duong, Karen Gomez, Steve Salinas, Coral Garcia, Amanda Tsang, Christophe Morisseau, Bruce D. Hammock, Stevan Pecic, Ram Kandasamy
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Polypharmacology
Formalin
Orofacial
Enzyme inhibition
Structure-activity relationship studies
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000962
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