Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation

Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation

Abstract Background N4‐acetylcytidine (ac4C) represents a novel messenger RNA (mRNA) modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a crucial role in the initiation and progression of tumors by regulating mRNA functionality. However, its role in hepatocellula...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hailing Liu, Lei Xu, Shiwei Yue, Hongfei Su, Xing Chen, Qiumeng Liu, Hui Li, Huifang Liang, Xiaoping Chen, Jiefeng He, Zeyang Ding, Bixiang Zhang
Format:	Article
Language:	English
Published:	Wiley 2024-09-01
Series:	Cancer Communications
Subjects:	N4‐acetylcytidine N‐acetyltransferase 10 hepatocellular carcinoma mRNA translation targeted therapy
Online Access:	https://doi.org/10.1002/cac2.12595
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Biological Function and Mechanism of NAT10 in Cancer
by: Yufeng Han, et al.
Published: (2025-02-01)

Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond
by: Lin Jiao, et al.
Published: (2025-07-01)

Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2
by: Yan Feng, et al.
Published: (2024-12-01)

NAT10 promotes gastric cancer progression by enhancing the N4-acetylcytidine modification of TNC mRNA
by: Yu Chen, et al.
Published: (2025-03-01)

DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction
by: Guohua Huang, et al.
Published: (2025-08-01)

N4‐Acetylcytidine‐Mediated CD2BP2‐DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression
by: Hongyu Wang, et al.
Published: (2025-04-01)

Study on the effect of NAT10 on the polarization of macrophages in mice
by: ZHANG Xianzhong, et al.
Published: (2025-08-01)

Integrating Single‐Cell Transcriptomics and Machine Learning to Define an ac4C Gene Signature in Lung Adenocarcinoma
by: Yuan Wang, et al.
Published: (2025-08-01)

Pharmacogenomic insights into tuberculosis treatment shows the NAT2 genetic variants linked to hepatotoxicity risk: a systematic review and meta-analysis
by: Rashmi Mahajan, et al.
Published: (2024-12-01)

Pharmacogenomic heterogeneity of N-acetyltransferase 2: a comprehensive analysis of real world data in Indian tuberculosis patients and from literature and database review
by: Levin Thomas, et al.
Published: (2025-12-01)

Influence of the Acetylation Type on the Incidence of Isoniazid-Induced Hepatotoxicity in Patients with Newly Diagnosed Pulmonary Tuberculosis
by: N. M. Krasnova, et al.
Published: (2020-11-01)

Cross‐talk between phosphorylation and lysine acetylation in a genome‐reduced bacterium
by: Vera van Noort, et al.
Published: (2012-02-01)

Exploring the role of N-acetyltransferases in diseases: a focus on N-acetyltransferase 9 in neurodegeneration
by: Prajakta Deshpande, et al.
Published: (2025-10-01)

NAA10 (N-Alpha-Acetyltransferase 10): A Multifunctional Regulator in Development, Disease, and Cancer
by: Zeng Quan Yang, et al.
Published: (2025-06-01)

A pan-cancer analysis of the oncogenic role of N-acetyltransferase 8 like in human cancer
by: Jiamin Chen, et al.
Published: (2024-12-01)

The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression
by: Zhuoran Gu, et al.
Published: (2024-12-01)

Association of NAT2 promoter hypermethylation with susceptibility to hepatotoxicity due to antituberculosis drugs and biomarker potential
by: Jiraphun Jittikoon, et al.
Published: (2025-03-01)

eEF2K as an important kinase associated with cancer survival and prognosis
by: Nan Wang, et al.
Published: (2024-11-01)

Influence of the NAT2 gene polymorphic markers on the effectiveness and safety of treatment in patients with newly diagnosed pulmonary tuberculosis based on peripheral red blood cell dynamics
by: N. M. Krasnova, et al.
Published: (2022-01-01)

eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle
by: Hidetaka Katow, et al.
Published: (2024-09-01)

A Personalized Approach to the Treatment of Primary Open-Angle Glaucoma
by: A. L. Onishchenko, et al.
Published: (2021-10-01)

Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function.
by: Melody D Fulton, et al.
Published: (2024-12-01)

N-acetyltransferase 10 Promotes Cervical Cancer Progression Via N4-acetylation of SLC7A5 mRNA
by: Peili Liang, et al.
Published: (2025-02-01)

Yin Yang 1 protein-activated N-acetyltransferase 10 drives cell malignant progression of osteosarcoma through ac4C acetylation of integrin β3
by: Fan Yang, et al.
Published: (2025-08-01)

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum
by: Wu-yun LÜ, et al.
Published: (2020-07-01)

Multiple Acquisitions of XopJ2 Effectors in Populations of Xanthomonas perforans
by: Anuj Sharma, et al.
Published: (2024-10-01)

eEF2K—a new target in breast cancers with combined inactivation of p53 and PTEN
by: Hege G Russnes, et al.
Published: (2014-12-01)

Inhibition of eEF2 kinase ameliorates hepatic injury induced by ACR through regulation of the MAPK pathway
by: Zhi-Ming Li, et al.
Published: (2025-09-01)

Licochalcone A suppresses pancreatic ductal adenocarcinoma progression by targeting eEF2K-mediated pyroptosis
by: Junjie Peng, et al.
Published: (2025-06-01)

Depletion of Fat Mass and Obesity‐Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)‐Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging
by: Fan Wang, et al.
Published: (2025-07-01)

MYST2 histone acetyltransferase promotes lung adenocarcinoma progression by regulating the p38 MAPK signaling pathway
by: Zhiang Huang, et al.
Published: (2025-01-01)

Resistance Exercise in Treating Heart Failure with Preserved Ejection Fraction (HFpEF) and Obesity: Targeting Skeletal Muscle Abnormalities and Ectopic Adipose Depots
by: Daniel J. McDonough
Published: (2025-02-01)

Function of eEF-1γ in the nucleus in response to insulin in hepatocellular carcinoma cells
by: Abu Jubayer Hossain, et al.
Published: (2025-05-01)

Aptamer‑mediated modulation of eEF1 enhances salt stress tolerance in rice
by: Yongxiang Huang, et al.
Published: (2025-07-01)

eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma
by: Jianxun Song, et al.
Published: (2022-03-01)

The euchromatic histone mark H3K36me3 preserves heterochromatin through sequestration of an acetyltransferase complex in fission yeast
by: Paula R. Georgescu, et al.
Published: (2020-01-01)

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6’)-Im
by: Clyde A. Smith, et al.
Published: (2017-11-01)

Multidimensional Regulatory Mechanisms and Targeting Strategies of the eEF1 Family in RNA Virus Infection
by: Xin Wang, et al.
Published: (2025-05-01)

Transcriptome-wide study of mRNAs modified by m6A RNA methylation in the testis development of dairy goats
by: Xinyang Ren, et al.
Published: (2025-12-01)

Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K
by: Jeff C Liu, et al.
Published: (2014-10-01)