Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation

Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation

Abstract Background N4‐acetylcytidine (ac4C) represents a novel messenger RNA (mRNA) modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a crucial role in the initiation and progression of tumors by regulating mRNA functionality. However, its role in hepatocellula...

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Bibliographic Details
Main Authors: Hailing Liu, Lei Xu, Shiwei Yue, Hongfei Su, Xing Chen, Qiumeng Liu, Hui Li, Huifang Liang, Xiaoping Chen, Jiefeng He, Zeyang Ding, Bixiang Zhang
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Cancer Communications
Subjects:
N4‐acetylcytidine
N‐acetyltransferase 10
hepatocellular carcinoma
mRNA translation
targeted therapy
Online Access:https://doi.org/10.1002/cac2.12595
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https://doi.org/10.1002/cac2.12595

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