NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide

NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide

Aims: The small conductance calcium activated potassium channel (KCNN1-3; KCa2.1–3) is recognized as a possible new anti-arrhythmic drug target for treatment of atrial fibrillation (AF). The aim of this study is to investigate potential ventricular effects of KCa2 channel inhibition under normal, br...

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Main Authors: Yannan Yan, Lea Abildgaard, Mark Alexander Skarsfeldt, Sofia Hammami Bomholtz, Ulrik Sørensen, Anders Gaarsdal Holst, Morten Grunnet, Jonas Goldin Diness, Bo Hjorth Bentzen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:International Journal of Cardiology: Heart & Vasculature
Subjects:
KCa2 channels
SK channels
Hypokalemia
QT-interval
Pharmacology
Arrhythmia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906725001022
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