Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion

Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion

Abstract The hepatocyte growth factor (HGF) along with its receptor (c-MET) are crucial in preserving standard cellular physiological activities, and imbalances in the c-MET signaling pathway can lead to the development and advancement of tumors. It has been extensively demonstrated that immune chec...

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Bibliographic Details
Main Authors: Yang Xia, Chunye Huang, Min Zhong, Hongguang Zhong, Ruiwen Ruan, Jianping Xiong, Yangyang Yao, Jing Zhou, Jun Deng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Cellular
Mesenchymal epithelial transition factor, Tumor microenvironment, PD
1/PD
L1 inhibitors, c
MET inhibitors, HGF/c
MET signaling pathway
Online Access:https://doi.org/10.1186/s12964-025-02033-1
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https://doi.org/10.1186/s12964-025-02033-1

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