Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation in Cryptococcus neoformans

Evidence for the role of Irk2 and Irk5 in ATP and metabolism regulation in Cryptococcus neoformans

IntroductionCryptococcus neoformans, a human fungal pathogen, harbors the kinases Irk2 and Irk5, which are classified within the APH phosphotransferase, AGC/YANK protein kinase, and diacylglycerol kinase-like kinase families. Both Irk2 and Irk5 are pivotal for virulence during lung and brain infecti...

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Bibliographic Details
Main Authors: Yuanyuan Ma, Jianhua Qu, Mingming Xu, Nuoya Zhou, Xiaoya Chen, Yu Han, Peng Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cryptococcosis
Irk2
Irk5
ATP
proteome
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1600041/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1600041/full

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