Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke
Stroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/8887012 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560670195843072 |
|---|---|
| author | Nathan T. Lee Fatimah Ahmedy Natiara Mohamad Hashim Khin Nyein Yin Kai Ling Chin |
| author_facet | Nathan T. Lee Fatimah Ahmedy Natiara Mohamad Hashim Khin Nyein Yin Kai Ling Chin |
| author_sort | Nathan T. Lee |
| collection | DOAJ |
| description | Stroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. This review assesses the recent evidence on the association between the BDNF polymorphism and aphasia recovery in poststroke patients. The article highlights BNDF polymorphism characteristics, speech and language interventions delivered, and the influence of BNDF polymorphism on poststroke aphasia recovery. We conducted a literature search through PubMed and Google Scholar with the following terms: “brain derived-neurotrophic factor” and “aphasia” for original articles from January 2000 until June 2020. Out of 69 search results, a detailed selection process produced a total of 3 articles that met the eligibility criteria. All three studies included Val66Met polymorphism as the studied human BDNF gene. One of the studies demonstrated insufficient evidence to conclude that BDNF polymorphism plays a role in poststroke aphasia recovery. The remaining two studies have shown that Met allele genotype (either single or double nucleotides) was associated with poor aphasia recovery, in either acute or chronic stroke. Carriers of the Val66Met polymorphism of BDNF gave a poorer response to aphasia intervention and presented with more severe aphasia. |
| format | Article |
| id | doaj-art-64e5ee97deea4ed1a6fd384a90bc3ec9 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-64e5ee97deea4ed1a6fd384a90bc3ec92025-02-03T01:27:00ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/88870128887012Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after StrokeNathan T. Lee0Fatimah Ahmedy1Natiara Mohamad Hashim2Khin Nyein Yin3Kai Ling Chin4Rehabilitation Medicine Unit, Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaRehabilitation Medicine Unit, Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaDepartment of Rehabilitation Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sg. Buloh, MalaysiaDepartment of Surgery, Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaStroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. This review assesses the recent evidence on the association between the BDNF polymorphism and aphasia recovery in poststroke patients. The article highlights BNDF polymorphism characteristics, speech and language interventions delivered, and the influence of BNDF polymorphism on poststroke aphasia recovery. We conducted a literature search through PubMed and Google Scholar with the following terms: “brain derived-neurotrophic factor” and “aphasia” for original articles from January 2000 until June 2020. Out of 69 search results, a detailed selection process produced a total of 3 articles that met the eligibility criteria. All three studies included Val66Met polymorphism as the studied human BDNF gene. One of the studies demonstrated insufficient evidence to conclude that BDNF polymorphism plays a role in poststroke aphasia recovery. The remaining two studies have shown that Met allele genotype (either single or double nucleotides) was associated with poor aphasia recovery, in either acute or chronic stroke. Carriers of the Val66Met polymorphism of BDNF gave a poorer response to aphasia intervention and presented with more severe aphasia.http://dx.doi.org/10.1155/2021/8887012 |
| spellingShingle | Nathan T. Lee Fatimah Ahmedy Natiara Mohamad Hashim Khin Nyein Yin Kai Ling Chin Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke Behavioural Neurology |
| title | Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke |
| title_full | Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke |
| title_fullStr | Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke |
| title_full_unstemmed | Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke |
| title_short | Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke |
| title_sort | brain derived neurotrophic factor polymorphism and aphasia after stroke |
| url | http://dx.doi.org/10.1155/2021/8887012 |
| work_keys_str_mv | AT nathantlee brainderivedneurotrophicfactorpolymorphismandaphasiaafterstroke AT fatimahahmedy brainderivedneurotrophicfactorpolymorphismandaphasiaafterstroke AT natiaramohamadhashim brainderivedneurotrophicfactorpolymorphismandaphasiaafterstroke AT khinnyeinyin brainderivedneurotrophicfactorpolymorphismandaphasiaafterstroke AT kailingchin brainderivedneurotrophicfactorpolymorphismandaphasiaafterstroke |