A novel in-vitro expression assay by LC/MS/MS enables multi-antigen mRNA vaccine characterization

A novel in-vitro expression assay by LC/MS/MS enables multi-antigen mRNA vaccine characterization

Abstract The new era of messenger RNA (mRNA) vaccines has led to development of a novel, state-of-the-art characterization method for this class of molecules. Currently, flow cytometry-based assays with antigen-specific antibodies are utilized for monitoring in-vitro expression (IVE) of mRNA. Here w...

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Main Authors: Hanliu Leah Wang, Kimia Kajbaf, Brian C. Gau, Andrew W. Dawdy, Rachel Edwards, Bradley Bare, Gianna Raymundo, Jose Iturrizaga, Chase Ernsky, Michael Walker, Emilia B. Byrne, James Boslett, Adam Campbell, Roman Matthessen, Ben Goffin, David Cirelli, Jason C. Rouse, Robbe Van Pottelberge, Olga V. Friese
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94616-8
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https://doi.org/10.1038/s41598-025-94616-8

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