Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster

Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster

BackgroundThe COVID-19 pandemic demanded diverse vaccination strategies, and there is significant interest in their effectiveness in generating a robust immune response. In Brazil, the use of CoronaVac was crucial in reducing mortality; however, heterologous booster doses were necessary to enhance m...

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Main Authors: Shayane Martins Rodrigues Gomes, Marcelo Ribeiro-Alves, Roberto Stefan de Almeida Ribeiro, Andréia Carolinne de Souza Brito, Vinicius da Cunha Lisboa, Samara Galdino de Azevedo, Jeane de Souza Nogueira, Leda dos Reis Castilho, Luís Cristóvão Sobrino Pôrto, Silvia Amaral Gonçalves da Silva, Patrícia Maria Lourenço Dutra, Wânia Ferraz Pereira Manfro, Luciana Silva Rodrigues
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
CoronaVac
humoral immunity
cytokines
heterologous booster
healthcare workers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576430/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576430/full

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