The identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism

The identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism

6-Nitrodopamine (6-ND) has potent positive chronotropic and inotropic effects. At a very low dose, i.e., 10 fM, it causes potentiation of the positive chronotropic effects induced by catecholamines in the rat atria, indicating a distinct mechanism of action. Cyclase-associated proteins (CAP-1 and CA...

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Main Authors: Irene Cipollone, Vittoria Monaco, José Britto-Júnior, Antonio Tiago Lima, Edson Antunes, Andre Sampaio Pupo, Ilaria Iacobucci, Flora Cozzolino, Maria Monti, Silvia Parisi, Giuseppina Divisato, Emanuela Cascone, Alfonso De Simone, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Vincenzo Santagada, Beatrice Severino, Rosa Sparaco, Pierfrancesco Cinque, Stefania Vertuccio, Giuseppe Caliendo, Gilberto De Nucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
dopamine
adrenaline
nitro-catecholamine
stromal interaction molecule 1
cyclase-associated proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1597035/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1597035/full

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