Signaling pathways and molecular mechanisms involved in the onset and progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); a focus on Notch3 signaling

Signaling pathways and molecular mechanisms involved in the onset and progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); a focus on Notch3 signaling

Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominantly inherited cerebral small-vessel disease (SVD). CADASIL has diverse clinical features such as migraine with aura, dementia, and recurrent strokes, and is caused by...

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Bibliographic Details
Main Authors: Parasta Heidari, Motahareh Taghizadeh, Omid Vakili
Format: Article
Language:English
Published: BMC 2025-04-01
Series:The Journal of Headache and Pain
Subjects:
CADASIL
NOTCH3
Signal transduction
Genetics
Cerebral small vessel disease
Online Access:https://doi.org/10.1186/s10194-025-02025-z
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https://doi.org/10.1186/s10194-025-02025-z

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