DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

Summary: A healthy metabolism relies on precise regulation of anabolic and catabolic pathways. While insulin deficiency impairs anabolism, insulin resistance in obesity causes metabolic dysfunction, especially via altered brain insulin receptor (IR) activity. Density-enhanced phosphatase 1 (DEP-1) n...

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Bibliographic Details
Main Authors: Simran Chopra, Otsuware Linda-Josephine Kadiri, Jannis Ulke, Robert Hauffe, Wenke Jonas, Sahar Cheshmeh, Luisa Schmidt, Christopher A. Bishop, Selma Yagoub, Mareike Schell, Michaela Rath, Janine Krüger, Rachel N. Lippert, Marcus Krüger, Kai Kappert, André Kleinridders
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013354
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