Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.

Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have been highly successful in the treatment of cancer. While PD-1 expression has been widely investigated, its role in CD4+ effector T cells in the setting of health and cancer remains unclear, particularly in the setting...

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Bibliographic Details
Main Authors: Brittany A Goods, Amanda L Hernandez, Daniel E Lowther, Liliana E Lucca, Benjamin A Lerner, Murat Gunel, Khadir Raddassi, Vlad Coric, David A Hafler, J Christopher Love
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181538&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181538&type=printable

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