Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin

Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin

Huntingtin-associated protein 1 (HAP1) is a crucial component of the stigmoid body (STB) and is recognized as a neuroprotective interactor with causative proteins for several neurodegenerative disorders (NDs). Due to HAP1 protectivity, brain regions rich in STB/HAP1 are typically shielded from neuro...

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Bibliographic Details
Main Authors: Marya Afrin, Md Nabiul Islam, Mirza Mienur Meher, Mir Rubayet Jahan, Kanako Nozaki, Koh-hei Masumoto, Akie Yanai, Koh Shinoda
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neuroanatomy
Subjects:
HAP1
stigmoid body
serotonergic neuron
neurodegenerative disorder
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2025.1625793/full
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https://www.frontiersin.org/articles/10.3389/fnana.2025.1625793/full

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