GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks

GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks

Abstract Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs), epigenetic mechanisms and genetic variants. Despi...

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Main Authors: Aryan Kamal, Christian Arnold, Annique Claringbould, Rim Moussa, Nila H Servaas, Maksim Kholmatov, Neha Daga, Daria Nogina, Sophia Mueller‐Dott, Armando Reyes‐Palomares, Giovanni Palla, Olga Sigalova, Daria Bunina, Caroline Pabst, Judith B Zaugg
Format: Article
Language:English
Published: Springer Nature 2023-04-01
Series:Molecular Systems Biology
Subjects:
enhancers
gene regulatory networks
macrophage biology
multiomics data integration
transcriptional regulation
Online Access:https://doi.org/10.15252/msb.202311627
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https://doi.org/10.15252/msb.202311627

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