Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain

Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain

Abstract Introduction There is a high unmet need for safe and effective non-opioid medicines to treat moderate to severe pain without risk of addiction. Voltage-gated sodium channel 1.8 (NaV1.8) is a genetically and pharmacologically validated pain target that is selectively expressed in peripheral...

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Bibliographic Details
Main Authors: Jeremiah D. Osteen, Swapna Immani, Tim L. Tapley, Tim Indersmitten, Nicole W. Hurst, Tiffany Healey, Kathleen Aertgeerts, Paul A. Negulescu, Sandra M. Lechner
Format: Article
Language:English
Published: Adis, Springer Healthcare 2025-01-01
Series:Pain and Therapy
Subjects:
Moderate to severe pain
NaV1.8
Non-opioid analgesic
Selective pain signal inhibitor
Suzetrigine
VX-548
Online Access:https://doi.org/10.1007/s40122-024-00697-0
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https://doi.org/10.1007/s40122-024-00697-0

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