HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models
The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use we...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/760734 |
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| _version_ | 1832561087573131264 |
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| author | Jing Wu Jessie L. Norris Yujiang Jia Ning Wang |
| author_facet | Jing Wu Jessie L. Norris Yujiang Jia Ning Wang |
| author_sort | Jing Wu |
| collection | DOAJ |
| description | The preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission. |
| format | Article |
| id | doaj-art-642c0261147f4dc99cef36f1854a325a |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-642c0261147f4dc99cef36f1854a325a2025-02-03T01:25:54ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/760734760734HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical ModelsJing Wu0Jessie L. Norris1Yujiang Jia2Ning Wang3National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, ChinaNational Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, ChinaDepartment of Preventive Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232, USANational Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Beijing 102206, ChinaThe preventative effects of antiretroviral therapy for people with HIV have been debated since they were first raised. Models commenced studying the preventive effects of treatment in the 1990s, prior to initial public reports. However, the outcomes of the preventive effects of antiretroviral use were not consistent. Some outcomes of dynamic models were based on unfeasible assumptions, such as no consideration of drug resistance, behavior disinhibition, or economic inputs in poor countries, and unrealistic input variables, for example, overstated initiation time, adherence, coverage, and efficacy of treatment. This paper reviewed dynamic mathematical models to ascertain the complex effects of ART on HIV transmission. This review discusses more conservative inputs and outcomes relative to antiretroviral use in HIV infections in dynamic mathematical models. ART alone cannot eliminate HIV transmission.http://dx.doi.org/10.1155/2014/760734 |
| spellingShingle | Jing Wu Jessie L. Norris Yujiang Jia Ning Wang HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models The Scientific World Journal |
| title | HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models |
| title_full | HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models |
| title_fullStr | HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models |
| title_full_unstemmed | HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models |
| title_short | HIV Treatment as Prevention: Contradictory Perspectives from Dynamic Mathematical Models |
| title_sort | hiv treatment as prevention contradictory perspectives from dynamic mathematical models |
| url | http://dx.doi.org/10.1155/2014/760734 |
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