Enhancer of zeste homolog 1/2 dual inhibitor valemetostat outperforms enhancer of zeste homolog 2-selective inhibitors in reactivating latent HIV-1 reservoirs ex vivo

Enhancer of zeste homolog 1/2 dual inhibitor valemetostat outperforms enhancer of zeste homolog 2-selective inhibitors in reactivating latent HIV-1 reservoirs ex vivo

For the eradication of human immunodeficiency virus type 1 (HIV-1) provirus from people living with HIV-1, reactivation of latently HIV-1-infected cells is essential. Although several latency reversing agents have been identified, eradication of HIV-infected cells has been a challenge. Here, we inve...

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Bibliographic Details
Main Authors: Ayako Sedohara, Tomohiko Koibuchi, Makoto Yamagishi, Michiko Koga, Kotaro Arizono, Kazuhiko Ikeuchi, Tadashi Kikuchi, Makoto Saito, Eisuke Adachi, Takeya Tsutsumi, Daisuke Honma, Kazushi Araki, Kaoru Uchimaru, Hiroshi Yotsuyanagi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
HIV-1 reservoir
latency reversing agents
EZH1/2 dual inhibitor
valemetostat
suberoylanilide hydroxamic acid
GSK126
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1581330/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1581330/full

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