Identification of a novel AGO2 variant causing LESKRES in a Chinese family with intellectual disability

BackgroundLessel-Kreienkamp syndrome (LESKRES, MIM #619149), an autosomal dominant genetic disorder caused by variants in AGO2 (MIM*606229), primarily leads to neurodevelopmental symptoms.ObjectiveThis study aims to investigate the genetic etiology of a family with intellectual disability.MethodsWho...

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Bibliographic Details
Main Authors: Shufa Yang, Wei Song, Yousheng Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
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Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1598462/full
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