Pretreatment with Notoginsenoside R1 enhances the efficacy of neonatal rat mesenchymal stem cell transplantation in model of myocardial infarction through regulating PI3K/Akt/FoxO1 signaling pathways

Pretreatment with Notoginsenoside R1 enhances the efficacy of neonatal rat mesenchymal stem cell transplantation in model of myocardial infarction through regulating PI3K/Akt/FoxO1 signaling pathways

Abstract Background Although stem cell transplantation is a promising approach for the treatment of myocardial infarction (MI), there are still some problems faced such as the low survival rate of stem cells. Here, we investigated the role of Notoginsenoside R1 (NGR1) pretreatment in improving the e...

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Bibliographic Details
Main Authors: Hao Cai, Xiao-jing Han, Zhi-rong Luo, Qiang-li Wang, Ping-ping Lu, Fang-fang Mou, Zhi-nan Zhao, Dan Hu, Hai-dong Guo
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Stem Cell Research & Therapy
Subjects:
Notoginsenoside R1
Bone marrow mesenchymal stem cell
Transplantation
Myocardial infarction
Signaling pathway
Online Access:https://doi.org/10.1186/s13287-024-04039-x
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https://doi.org/10.1186/s13287-024-04039-x

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