Distinct potency of compounds targeting the T1R3 subunit in modulating the response of human sweet and umami taste receptors

Distinct potency of compounds targeting the T1R3 subunit in modulating the response of human sweet and umami taste receptors

Abstract The heterodimeric G-protein-coupled receptors T1R2/T1R3 and T1R1/T1R3 have been identified as sweet and umami taste receptors, respectively, and both of these receptors share the T1R3 subunit. Previous research has indirectly indicated functional differences in the T1R3 subunit between the...

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Bibliographic Details
Main Authors: Maiko Kawasaki, Yuta Kidera, Ryusei Goda, Chiaki Taketani, Misato Ide, Wataru Fujii, Tomoya Nakagita, Takumi Misaka
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Taste
Sweet
Umami
Taste receptor
Positive allosteric modulator (PAM)
Negative allosteric modulator (NAM)
Online Access:https://doi.org/10.1038/s41598-025-11636-0
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https://doi.org/10.1038/s41598-025-11636-0

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