Exploring the principles behind antibiotics with limited resistance

Exploring the principles behind antibiotics with limited resistance

Abstract Antibiotics that target multiple cellular functions are anticipated to be less prone to bacterial resistance. Here we hypothesize that while dual targeting is crucial, it is not sufficient in preventing resistance. Only those antibiotics that simultaneously target membrane integrity and blo...

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Main Authors: Elvin Maharramov, Márton Simon Czikkely, Petra Szili, Zoltán Farkas, Gábor Grézal, Lejla Daruka, Eszter Kurkó, Léna Mészáros, Andreea Daraba, Terézia Kovács, Bence Bognár, Szilvia Juhász, Balázs Papp, Viktória Lázár, Csaba Pál
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56934-3
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https://doi.org/10.1038/s41467-025-56934-3

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