Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules

Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules

IntroductionIn vertebrate limb morphogenesis, wingless-related integration site (Wnt) proteins and fibroblast growth factors (Fgfs) secreted from the apical ectodermal ridge (AER) coordinate proximodistal outgrowth. Fgfs also sustain sonic hedgehog (Shh) in the zone of polarizing activity (ZPA). Shh...

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Main Authors: Jessica C. Britton, Anett Somogyi-Leatigaga, Billy A. Watson, Endika Haro, Cassidy G. Mulder, Kari D. Kennedy, Allen M. Cooper, Kristen L. Whitley, Ruth-Love Yeboah, Jeanyoung Kim, Micah C. Yu, Jairo D. Campos, Japhet Amoah, Shimako Kawauchi, Eunyoung Kim, Charmaine U. Pira, Kerby C. Oberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Lhx2
vertebrate limb development
cis-regulatory module
gene regulation
FGFs
Wnt
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1552716/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1552716/full

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