Molecular basis of ligand-dependent Nurr1-RXRα activation

Molecular basis of ligand-dependent Nurr1-RXRα activation

Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha (RXRα) (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechanisms. Here, we show that RXRα ligands activate Nurr1...

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Bibliographic Details
Main Authors: Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
nuclear receptors
NMR spectroscopy
ligand binding
transcription factors
biophysics
protein-protein interaction
Online Access:https://elifesciences.org/articles/85039
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https://elifesciences.org/articles/85039

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