Decoding the impact of exercise and αCGRP signaling on murine post-traumatic osteoarthritis progression

Abstract Background Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage breakdown, subchondral bone remodeling, and inflammation. Mechanical stress, such as exercise, can influence OA progression, acting as either a therapeutic intervention or a risk factor dependi...

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Main Authors: Patrick Pann, Paul Kalke, Verena Maier, Nicole Schäfer, Hauke Clausen-Schaumann, Arndt F. Schilling, Susanne Grässel
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Arthritis Research & Therapy
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Online Access:https://doi.org/10.1186/s13075-025-03589-6
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