Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow

ABSTRACT Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the allosteric inactivation of pyruvate...

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Main Authors: Fukang She, Brent W. Anderson, Daven B. Khana, Shenwei Zhang, Wieland Steinchen, Danny K. Fung, Nathalie G. Lesser, Lauren N. Lucas, David M. Stevenson, Theresa J. Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D. Wang
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mSystems
Subjects:
pyruvate kinase
gluconeogenesis
overflow metabolism
allosteric regulation
Online Access:https://journals.asm.org/doi/10.1128/msystems.01131-24
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https://journals.asm.org/doi/10.1128/msystems.01131-24

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