Basophil-derived exosomes exacerbate systemic lupus erythematosus by regulating B-cell proliferation via miR-24550

Basophil-derived exosomes exacerbate systemic lupus erythematosus by regulating B-cell proliferation via miR-24550

Abstract Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease where B-cell proliferation and activation play a pivotal role in pathogenesis. While the role of basophils in SLE is recognized, the impact of basophil-derived exosomes on B-cell proliferation and activation has n...

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Main Authors: Jiaxuan Chen, Shuzhen Liao, Jiaqi Lun, Xing Lu, Bitang Huang, Xiaoxian Liu, Xiaowei Xu, Lawei Yang, Fengbiao Guo, Liuyong You, Haiyan Xiao, Hua-Feng Liu, Qingjun Pan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medicine
Subjects:
Systemic lupus erythematosus
Basophils
B cells
Exosomes
miR-24550
Online Access:https://doi.org/10.1186/s12916-025-04324-3
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https://doi.org/10.1186/s12916-025-04324-3

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