A Mouse Model of Polycystic Ovary Syndrome Established Through Subcutaneous Administration of Letrozole Sustained-Release Pellets and Hepatic Transcriptome Analysis

A Mouse Model of Polycystic Ovary Syndrome Established Through Subcutaneous Administration of Letrozole Sustained-Release Pellets and Hepatic Transcriptome Analysis

Objective Prepubertal mice are administered subcutaneously with letrozole sustained-release pellets behind the neck and treated with a high-fat diet to establish a mouse model of polycystic ovary syndrome (PCOS). The liver transcriptomes of the model mice are compared with those of the placebo contr...

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Bibliographic Details
Main Authors: XU Qiuyu, YAN Guofeng, FU Li, FAN Wenhua, ZHOU Jing, ZHU Lian, QIU Shuwen, ZHANG Jie, WU Ling
Format: Article
Language:zho
Published: Editorial Office of Laboratory Animal and Comparative Medicine 2025-04-01
Series:Shiyan dongwu yu bijiao yixue
Subjects:
letrozole
polycystic ovary syndrome
liver
transcriptome sequencing
mice
Online Access:https://www.slarc.org.cn/dwyx/article/2025/1674-5817/1674-5817-2025-45-2-119.shtml
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https://www.slarc.org.cn/dwyx/article/2025/1674-5817/1674-5817-2025-45-2-119.shtml

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