Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model

Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model

Abstract Background Patient-derived induced pluripotent stem cell (iPSCs) represents a powerful tool for elucidating the underlying disease mechanisms. Macular corneal dystrophy (MCD) is an intractable and progressive bilateral corneal disease affecting the corneal stroma due to mutation/s in carboh...

Full description

Saved in:
Bibliographic Details
Main Authors: Divyani Nayak, Shivapriya Shivakumar, Rohit Shetty, K. N. Prashanthi, Arkasubhra Ghosh, Nallathambi Jeyabalan, Koushik Chakrabarty
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Macular corneal dystrophy
Corneal stromal cells
Mitochondrial damage
Pluripotent stem cells
Differentiation
Autophagy
Online Access:https://doi.org/10.1186/s13287-024-04016-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13287-024-04016-4

Similar Items