PIT-1/SF-1-positive pituitary tumors in patients with acromegaly: transcriptomic perspective

PIT-1/SF-1-positive pituitary tumors in patients with acromegaly: transcriptomic perspective

Abstract Neuroendocrine pituitary tumors (PitNETs) are classified based on clinical manifestation and expression of pituitary cell lineage-specific transcription factors (TFs) and hormones. A subtype of tumors in patients with acromegaly was found to express PIT-1 and SF-1 TFs, two markers of distin...

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Bibliographic Details
Main Authors: Julia Rymuza, Qilin Zhang, Mateusz Bujko
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Acta Neuropathologica Communications
Subjects:
Pituitary neoplasms
Growth hormone-secreting pituitary adenoma
Gene expression profiling
Single-cell gene expression analysis
Transcription factors
Online Access:https://doi.org/10.1186/s40478-025-02091-z
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https://doi.org/10.1186/s40478-025-02091-z

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