LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer

LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer

Abstract Background Lemur Tail Kinase 3 (LMTK3) promotes cell proliferation, invasiveness and therapy resistance, and its expression correlates with poor survival in several different malignancies, including breast cancer. Crosstalk through extracellular vesicles (EVs) is an increasingly appreciated...

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Main Authors: Mark Samuels, Christos Karakostas, Simoni Besta, Andrea Lauer Betrán, Katerina Tsilingiri, Charlotte Turner, Reza Shirazi Nia, Niloufar Poudine, Richard Goodyear, William Jones, Apostolos Klinakis, Georgios Giamas
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Subjects:
LMTK3
Rab7
Extracellular Vesicles
Breast Cancer
Monocytes
Macrophages
Online Access:https://doi.org/10.1186/s12943-025-02346-2
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https://doi.org/10.1186/s12943-025-02346-2

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