Flexible integration of spatial and expression information for precise spot embedding via ZINB-based graph-enhanced autoencoder

Abstract Domain identification is a critical problem in spatially resolved transcriptomics data analysis, which aims to identify distinct spatial domains within a tissue that maintain both spatial continuity and expression consistency. The degree of coupling between expression data and spatial infor...

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Bibliographic Details
Main Authors: Jiacheng Leng, Jiating Yu, Ling-Yun Wu, Hongyang Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07965-5
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