Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals

Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals

Summary: Genome-wide association studies (GWASs) have identified over 100 signals associated with type 1 diabetes (T1D). However, it has been challenging to translate any given T1D GWAS signal into mechanistic insights, such as causal variants, their target genes, and the specific cell types involve...

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Main Authors: Ricardo D'Oliveira Albanus, Xiaoshan Zhang, Zeping Zhao, Henry J. Taylor, Xuming Tang, Yuling Han, Peter Orchard, Arushi Varshney, Tuo Zhang, Nandini Manickam, Michael R. Erdos, Narisu Narisu, Leland Taylor, Xiaxia Saavedra, Xinyi Liu, Aaron Zhong, Bo Li, Ting Zhou, Ali Naji, Chengyang Liu, Francis S. Collins, Stephen C.J. Parker, Shuibing Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008368
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