A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices

Abstract Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta‐lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in ther...

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Bibliographic Details
Main Authors: Conor J. O'Hanlon, Nick Holford, Brian J. Anderson, Mark Greaves, Lee Blackburn, Malcolm D. Tingle, Jacqueline A. Hannam
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13180
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