Optimized multiplex PCR-NGS for comprehensive HLA genotyping in Chinese populations: resolving ambiguities at high resolution

Optimized multiplex PCR-NGS for comprehensive HLA genotyping in Chinese populations: resolving ambiguities at high resolution

IntroductionAccurate human leukocyte antigen (HLA) genotyping is critical for organ transplantation to ensure donor-recipient compatibility. Conventional methods, such as sequence-based typing (SBT), often face challenges in resolving allelic ambiguities, particularly in highly polymorphic regions o...

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Main Authors: Cuello Garcia Haider, Binbin Sun, Yinfeng Wang, Zhoufan Zhang, Changling Cao, Yiying Zhu, Ouzaouit Abdelhak, Huiqiang Huang, Haitao Liu, Tingya Jiang, Xueping Dong, Yang Zhou, Yu Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
HLA matching
deep sequencing
next-generation sequencing
multilocus sequence typing
HLA alleles
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551173/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551173/full

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