SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program

SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program

Abstract Background Neuroblastoma, the most common pediatric extracranial solid tumor, has heterogeneous clinical outcomes ranging from malignant progression to spontaneous regression. With the highest frequency of the elusive spontaneous regression, low-risk INSS Stage 4S neuroblastoma represents a...

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Main Authors: Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Neuroblastoma
Intra-tumor cell heterogeneity
SLIT3
SLIT-ROBO signaling
Differentiation induction therapy
Online Access:https://doi.org/10.1186/s12967-025-06621-0
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https://doi.org/10.1186/s12967-025-06621-0

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