A novel machine-learning algorithm to screen for trisomy 21 in first-trimester singleton pregnancies

Background Antenatal screening for Trisomy 21 (T21) in the UK is performed primarily in the first trimester. Nuchal Translucency (NT), gestational age, Free β-HCG and PAPP-A are used in combination, creating the ‘combined’ test. Multivariate Gaussian distribution models then determine the chance of...

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Bibliographic Details
Main Authors: James Osborne, Chris Cockcroft, Carolyn Williams
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Obstetrics and Gynaecology
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Online Access:https://www.tandfonline.com/doi/10.1080/01443615.2025.2527111
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