Discovery of Balasubramide Derivative with Tissue‐Specific Anti‐Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1

Abstract Macrophage‐mediated inflammatory responses including pyroptosis are involved in the pathogenesis of sepsis and acute lung injury (ALI), for which there are currently no effective therapeutic treatments. The natural product (+)‐Balasubramide is an eight‐membered lactam compound extracted fro...

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Bibliographic Details
Main Authors: Jin‐Qian Song, Li‐Juan Shen, Hao‐Jie Wang, Qi‐Bing Liu, Lian‐Bao Ye, Kui Liu, Lei Shi, Bin Cai, Han‐Sen Lin, Tao Pang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.202410550
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